Efficacy of Decreased Dosage of Amoxicillin in an Eradication Remedy for Helicobacter pylori An infection in Sufferers on Hemodialysis: A Randomized Managed Trial – Summary – Digestion 2018, Vol. 97, No. 2

Systematic DNA Study for Fabry Disease in the End Stage Renal Disease Patients from a Southern Italy Area - FullText - Kidney and Blood Pressure Research 2018, Vol. 43, No. 4
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Sahara S.a· Sugimoto M.a,d· Ichikawa H.a· Kagami T.a· Sakao Y.f· Ohashi N.a· Horio Y.e· Sugimoto Okay.a· Kato A.b· Furuta T.c· Yasuda H.a

Creator affiliations

aFirst Division of Medication, Hamamatsu, Japan
bBlood Purification Unit, Hamamatsu, Japan
cHeart for Medical Analysis, Hamamatsu College Faculty of Medication, Hamamatsu, Japan
dDivision of Digestive Endoscopy, Shiga College of Medical Science Hospital, Otsu, Japan
eDivision of Gastroenterology, Municipal Kosai Hospital, Kosai, Japan
fHamana Clinic, Hamamatsu, Japan

Digestion 2018;97:163–169

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Article / Publication Particulars

First-Web page Preview

Abstract of Original Paper

Obtained: September 14, 2017
Accepted: November 04, 2017
Revealed on-line: January 08, 2018
Subject launch date: February 2018

Variety of Print Pages: 7
Variety of Figures: 4
Variety of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (On-line)

For added info: https://www.karger.com/DIG


Background: An optimum Helicobacter pylori-eradication routine for hemodialysis sufferers is but to be established due to totally different pharmacokinetics of amoxicillin concerned between hemodialysis sufferers and wholesome topics. We investigated to ascertain acceptable doses of amoxicillin for H. pylori an infection eradication in hemodialysis sufferers. Strategies: Of 409 hemodialysis sufferers screened for H. pylori an infection, 37 H. pylori-positive sufferers have been randomized to totally different 1-week eradication regimens: esomeprazole 20 mg twice a day (b.i.d.) and clarithromycin 200 mg b.i.d., plus amoxicillin at both 750 mg b.i.d. (group A; typical) or 250 mg b.i.d. (group B; experimental). Sixty-three sufferers with regular renal operate obtained the standard routine (group C). Profitable eradication was confirmed by urea breath testing. Outcomes: Eradication charges of group B (lowered amoxicillin-regimen) have been 84.2% in intention-to-treat evaluation and 88.9% in per-protocol evaluation, which have been related with group A (77.8 and 77.8%) and group C (74.6 and 81.0%). Nonetheless, the incidence of hostile occasions in group A was considerably greater than that in group C (22.2 vs. 5.1%, p = 0.027). Conclusions: In H. pylori-positive hemodialysis sufferers, amoxicillin at 250 mg b.i.d. could also be an acceptable scheme for eradication with equal results to the standard remedy and security results for hostile occasions.

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Article / Publication Particulars

First-Web page Preview

Abstract of Original Paper

Obtained: September 14, 2017
Accepted: November 04, 2017
Revealed on-line: January 08, 2018
Subject launch date: February 2018

Variety of Print Pages: 7
Variety of Figures: 4
Variety of Tables: 3

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (On-line)

For added info: https://www.karger.com/DIG

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