Extracorporeal Life Assist Group – ECMO and ECLS > COVID-19

Extracorporeal Life Support Organization - ECMO and ECLS > COVID-19
January 21, 2021 0 Comments



ELSO is offering this web site as a useful resource for facilities who could also be referred to as on to handle COVID-19 sufferers. As that is an rising infectious illness, the scientific knowledge is continually evolving. The contents of this web page will change quickly as new data develops. For actual time updates, please observe ELSO’s social media accounts at Twitter (@ELSOOrg and @ECMOed) and Fb (https://www.fb.com/ELSO.Org) in addition to the ECMOed COVID-19 web page (https://elso.weblog/class/2019ncov-2/)

Pointers for ECMO in COVID-19

NIH launched pointers for treating COVID-19 sufferers, acknowledging ECMO as a remedy choice within the vital care part. https://www.covid19treatmentguidelines.nih.gov/introduction/

ELSO has ready an in-depth set of pointers for ECMO in COVID-19 sufferers. These have been collaboratively developed by a world workforce of ECMO consultants. The rules embody: affected person choice standards, cannulation and decannulation methods, transport on ECMO, PPE and workers safety methods with ECMO, to moral dilemmas and high quality.

Steering Doc

Preliminary ELSO Steering Doc – printed within the ASAIO Journal:


We’re happy to launch ELSO`s Steering on ECMO in COVID-19. This doc has been authorised by the Government Committee and Chapter Chairs. Will probably be up to date as crucial.



Reporting COVID-19 Circumstances into the ELSO Registry

Reporting COVID-19 Circumstances into the ELSO Registry

Confirmed COVID-19 instances ought to make the most of the ICD-10 emergency code U07.1, 2019-nCoV acute respiratory illness as the first prognosis. In an effort to raised perceive the influence of COVID-19 on ECMO we’ve additionally added a query asking if a affected person has COVID-19.

There are 4 response choices:

COVID-19 Circumstances on ECMO within the ELSO Registry:

Complete COVID-19 Circumstances COVID-19
Suspected or Confirmed
Confirmed Circumstances
Complete counts of COVID-19 confirmed sufferers and rely of COVID-19 suspected however not confirmed by testing.
Sufferers who initiated ECMO at
least 90 days in the past
In-hospital Mortality
COVID-19 ECMO counts by ELSO Chapter
North America 2867
Europe 914
Asia Pacific 59
Latin America 179
Experiences counts of ECMO-supported suspected or confirmed COVID-19 instances by ELSO Chapter (supplied the chapter has at the very least 5 instances reported)



ECMO Associated COVID-19 Analysis

COVID-19 Vital Care Consortium

ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Illness (COVID-19 Vital Care Consortium) is a potential/retrospective multi-center brief interval incidence observational research of intensive care unit sufferers with COVID-19. 


EuroELSO has established a COVID-19 survey and has launched outcomes. That is an ongoing effort within the area and we are going to proceed to replace this part as extra outcomes change into obtainable.

Euro-ELSO Survey

COVID-19 Vital Care Consortium

Choose Scientific Literature concerning ECMO Use for COVID-19:

  • Authentic Analysis
    • Extracorporeal membrane oxygenation assist in COVID-19: a global cohort research of the Extracorporeal Life Assist Group registry. Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS, Fan E, Bartlett RH, Tonna JE, Hyslop R, Fanning JJ, Rycus PT, Hyer SJ, Anders MM, Agerstrand CL, Hryniewicz Ok, Diaz R, Lorusso R, Combes A, Brodie D; Extracorporeal Life Assist Group. Lancet. 2020 Oct 10;396(10257):1071-1078. doi: 10.1016/S0140-6736(20)32008-0. Epub 2020 Sep 25.PMID: 32987008
    • Extracorporeal membrane oxygenation for extreme acute respiratory misery syndrome related to COVID-19: a retrospective cohort research. Schmidt M, Hajage D, Lebreton G, Monsel A, Voiriot G, Levy D, Baron E, Beurton A, Chommeloux J, Meng P, Nemlaghi S, Bay P, Leprince P, Demoule A, Guidet B, Constantin JM, Fartoukh M, Dres M, Combes A; Groupe de Recherche Clinique en REanimation et Soins intensifs du Affected person en Insuffisance Respiratoire aiguE (GRC-RESPIRE) Sorbonne Université; Paris-Sorbonne ECMO-COVID investigators. Lancet Respir Med. 2020 Nov;8(11):1121-1131. doi: 10.1016/S2213-2600(20)30328-3. Epub 2020 Aug 13. PMID: 32798468
    • SARS-CoV-2 Does Not Unfold By means of Extracorporeal Membrane Oxygenation or Dialysis Membranes. Dres M, Burrel S, Boutolleau D, Voiriot G, Demoule A, Combes A, Lebreton G, Schmidt M. Am J Respir Crit Care Med. 2020 Aug 1;202(3):458-460. doi: 10.1164/rccm.202004-1339LE. PMID: 32525400
    • Extracorporeal membrane oxygenation in youngsters with COVID-19: Preliminary report from the collaborative EuroELSO potential survey. Di Nardo M, Hoskote A, Thiruchelvam T, Lillie J, Horan M, Belda Hofheinz S, Dupic L, Gimeno R, De Piero ME, Lo Coco V, Roeleveld P, Davidson M, Jones T, Broman LM, Lorusso R, Belohlavek J; EuroELSO Neonatal & Pediatric Working Group & collaborators on COVID-19. ASAIO J. 2020 Oct 1. doi: 10.1097/MAT.0000000000001309. On-line forward of print. PMID: 33009172
    • Ventilator-associated pneumonia in sufferers with SARS-CoV-2-associated acute respiratory misery syndrome requiring ECMO: a retrospective cohort research. Luyt CE, Sahnoun T, Gautier M, Vidal P, Burrel S, Pineton de Chambrun M, Chommeloux J, Desnos C, Arzoine J, Nieszkowska A, Bréchot N, Schmidt M, Hekimian G, Boutolleau D, Robert J, Combes A, Chastre J. Ann Intensive Care. 2020 Nov 23;10(1):158. doi: 10.1186/s13613-020-00775-4. PMID: 33230710
    • Extracorporeal Membrane Oxygenation for Sufferers With COVID-19 in Extreme Respiratory Failure. Mustafa AK, Alexander PJ, Joshi DJ, Tabachnick DR, Cross CA, Pappas PS, Tatooles AJ. JAMA Surg. 2020 Aug 11;155(10):990-2. doi: 10.1001/jamasurg.2020.3950. On-line forward of print. PMID: 32780089
    • Profitable Remedy of Pregnant and Postpartum Girls with Extreme COVID-19 Related Acute Respiratory Misery Syndrome with Extracorporeal Membrane Oxygenation. Barrantes JH, Ortoleva J, O’Neil ER, Suarez EE, Larson SB, Rali AS, Agerstrand C, Grazioli L, Chatterjee S, Anders M. ASAIO J. 2020 Nov 20. doi: 10.1097/MAT.0000000000001357. On-line forward of print. PMID: 33229971
  • Viewpoints
    • Planning and provision of ECMO companies for extreme ARDS through the COVID-19 pandemic and different outbreaks of rising infectious ailments. Ramanathan Ok, Antognini D, Combes A, Paden M, Zakhary B, Ogino M, MacLaren G, Brodie D, Shekar Ok. Lancet Respir Med. 2020 Could;8(5):518-526. doi: 10.1016/S2213-2600(20)30121-1. Epub 2020 Mar 20. PMID: 32203711
    • Getting ready for the Most Critically In poor health Sufferers With COVID-19: The Potential Position of Extracorporeal Membrane Oxygenation. MacLaren G, Fisher D, Brodie D. JAMA. 2020 Apr 7;323(13):1245-1246. doi: 10.1001/jama.2020.2342. PMID: 32074258
    • Provision of ECPR throughout COVID-19: proof, fairness, and moral dilemmas. Worku E, Gill D, Brodie D, Lorusso R, Combes A, Shekar Ok. Crit Care. 2020 Jul 27;24(1):462. doi: 10.1186/s13054-020-03172-2.PMID: 32718340
    • What’s new in ECMO for COVID-19? MacLaren G, Combes A, Brodie D. Intensive Care Med. 2020 Nov 12:1-3. doi: 10.1007/s00134-020-06284-z. On-line forward of print. PMID: 33180168
    • ECMO through the COVID-19 pandemic: when is it unjustified? Abrams D, Lorusso R, Vincent JL, Brodie D. Crit Care. 2020 Aug 17;24(1):507. doi: 10.1186/s13054-020-03230-9. PMID 32807189
    • ECMO for extreme ARDS related to COVID-19: now we all know we will, however ought to we? Shekar Ok, Slutsky AS, Brodie D. Lancet Respir Med. 2020 Nov;8(11):1066-1068. doi: 10.1016/S2213-2600(20)30357-X. Epub 2020 Aug 13. PMID: 32798470
    • COVID-19 and ECMO: the interaction between coagulation and inflammation-a narrative evaluate. Kowalewski M, Fina D, Słomka A, Raffa GM, Martucci G, Lo Coco V, De Piero ME, Ranucci M, Suwalski P, Lorusso R. Crit Care. 2020 Could 8;24(1):205. doi: 10.1186/s13054-020-02925-3.PMID: 32384917
    • COVID-19-associated acute respiratory misery syndrome: is a special strategy to administration warranted? Fan E, Beitler JR, Brochard L, Calfee CS, Ferguson ND, Slutsky AS, Brodie D. Lancet Respir Med. 2020 Aug;8(8):816-821. doi: 10.1016/S2213-2600(20)30304-0. Epub 2020 Jul 6.PMID: 32645311
    • Extracorporeal life assist for adults with acute respiratory misery syndrome. Combes A, Schmidt M, Hodgson CL, Fan E, Ferguson ND, Fraser JF, Jaber S, Pesenti A, Ranieri M, Rowan Ok, Shekar Ok, Slutsky AS, Brodie D. Intensive Care Med. 2020 Dec;46(12):2464-2476. doi: 10.1007/s00134-020-06290-1. Epub 2020 Nov 2.PMID: 33140180

COVID-19 Useful resource Facilities, Scientific Journal Websites

The New England Journal of Drugs: https://www.nejm.org/coronavirus

Journal of American Medical Affiliation: https://jamanetwork.com/journals/jama/pages/coronavirus-alert

Science: https://www.sciencemag.org/coronavirus-research-commentary-and-news?IntCmp=coronavirussiderail-128

The Lancet: https://www.thelancet.com/coronavirus?dgcid=kr_pop-up_tlcoronavirus20

Normal data concerning
the COVID-19 pandemic could be discovered at

Normal data concerning
the COVID-19 pandemic could be discovered at

Messages from ELSO’s President on COVID-19

An Replace on ECMO in COVID19 from ELSO’s President, Dr. Mark Ogino.
Posted Could 4, 2020.

ELSO’s response to COVID-19 from ELSO’s President, Dr. Mark Ogino. The usage of ECMO in treating COVID-19 sufferers.
Posted March 14, 2020.

Webinars & Podcasts


Vital care & ECMO within the period of COVID-19: why knowledge issues

On Jun 08, 2020 ELSO hosted a webinar: ‘Vital care & ECMO within the period of COVID-19: why knowledge issues’. Vital care & ECMO within the period of COVID-19: why knowledge issues! ELSO webinar, moderated by Dr. Robert Bartlett & Matt Paden, highlighting the present analysis underway centered on higher understanding the influence of COVID-19, and the position of extracorporeal assist and ICU care in sufferers with SARS-CoV-2 Coronavirus an infection. Matters & audio system:
ELSO Registry and the reside dashboard for COVID-19 Circumstances: Matt Paden & Ryan Barbaro
EuroELSO Survey on ECLS in COVID-19, Roberto Lorusso & Jan Bělohlávek
COVID-Vital Care Consortium, John Fraser & Heidi Dalton

On April 22, 2020 ELSO hosted a webinar ‘ECMO COVID-19 What we’ve discovered.’ Audio system & matters: Christian Bermudez – ECMO Middle Group and Regional Coordination; Holt Murray – Regional ECMO Coordination; 10 years in 10 minutes Erik Osborn – COVID-19 & ECMO Experiences & Administration; Tim Maul – Irritation & Coagulation for SARS-CoV-2 a Perfusionist’s Perspective; Troy Seelhammer – ECMO in COVID-19: Is There a Position for Bivalirudin? All slides obtainable at https://bit.ly/2RZpAHc

Watch the STS Webinar from Thursday, April twenty third – Webinar on COVID Disaster

Cardiothoracic surgeons across the globe rapidly tailored to the challenges offered by the COVID pandemic. Among the many points has been an elevated want for extracorporeal membrane oxygenation (ECMO), with out the required assets to fulfill the demand.

Clarify the position of the Extracorporeal Life Assist Group (ELSO) in guiding physicians and different practitioners by preparations for the COVID pandemic.

On Friday, April third, 2020 at 4:00pm Jap ELSO hosted a webinar: The Energy of Connection. In that webinar, we mentioned the ability of sharing data in real-time utilizing WhatsApp COVID19 chat rooms in order that we will share what we’re studying about COVID-19 sufferers on ECMO rapidly (Tammy Friedrich, Holli Williams, Amy Hackman). We additionally shared the experiences with COVID-19 sufferers on ECMO in Seattle (Jenelle Badulak), NYC (Cara Agerstrand), and Paris (Matthieu Schmidt). You possibly can view the webinar anytime above.

Getting ready to assist #COVID19 sufferers on #ECMO: first ELSO webinar devoted to the position of extracorporeal assist in sufferers with #SARSCoV2 an infection, audio system:
Dr. Ram Ramanathan
Dr. Kiran Shekar
Dr. Michael Matthay

Caregiver Sources


FDA Approves ECMO Use for Gear Throughout Pandemic

FDA launched steerage for business and FDA workers on Enforcement Coverage for Extracorporeal Membrane Oxygenation and Cardiopulmonary Bypass Gadgets In the course of the Coronavirus Illness 2019 (COVID-19) Public Well being Emergency.

Perfusion Process Drive

The Joint Perfusion COVID-19 Process Drive was assembled not too long ago with the primary perfusion skilled societies (AmSECT, AACP, ABCP) and extra companions. We’re proud to collaborate with all companions working towards the frequent aim of bettering COVID-19 affected person outcomes. Please be part of, if , which is free:

Business Companions:

Please discover the steerage from our business companions on COVID-19 and ECMO gear, equivalent to what’s presently recognized about COVID-19 in oxygenators.
Use_of_Getinge_oxygenators_in_Covid19_Internationl Letter.pdf

Getinge_COVID-19_MCP products_US Final_04042020.pdf

Xenios AG Additional Corporeal Life Assist (ECLS) merchandise in critically ailing sufferers affected by COVID-19

Information Media

https://www.nytimes.com/2020/04/26/well being/coronavirus-patient-ventilator.html?motion=click on&module=Highlight&pgtype=Homepage

Information article on treating COVID-19 sufferers with ECMO, referencing Michigan Drugs, Dr. Bartlett, and present ECMO Director Jonathan Haft: https://www.wxyz.com/information/coronavirus/rare-life-support-system-pioneered-by-u-of-m-doctor-helps-covid-19-patients

Use of ECMO in COVID-19 sufferers, ELSO, and historical past of ECMO: https://labblog.uofmhealth.org/rounds/when-ventilators-dont-help-covid-19-patients-might


In Vital Coronavirus Circumstances, Medical doctors Flip to Final-Ditch Lung Assist – WSJ



A ventilator wasn’t sufficient to deal with him for Covid-19. This machine grew to become his final probability for survival

Medical doctors in Arizona doubted that Dr. Karl Viddal was going to make it. The ventilator was working at its highest setting and nonetheless wasn’t sufficient for his lungs.

Learn in CNN: https://apple.information/AVyULfn_1ST-KmMYXmRG2vA


“Father of ECMO: When a Ventilator Isn’t Sufficient”:

Contained in the Battle to Save Houston’s Most Susceptible https://www.nytimes.com/interactive/2020/08/10/us/houston-hospital-coronavirus.html?referringSource=articleShare

Extracorporeal organs might save the sickest sufferers from Covid-19 https://www.medicaldevice-network.com/options/ecmo-covid-19-2/

https://well being.usnews.com/situations/coronavirus-and-your-health/articles/what-is-ecmo-for-covid-19

#VisualAbstract: Outcomes of COVID-19-related ARDS patients on extracorporeal membrane oxygenation




ECMO in COVID-19 an infection

The WHO is distributing an Interim Steering doc for the
“Medical administration of extreme acute respiratory an infection when Novel coronavirus (nCoV) an infection is suspected. (https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected)” The WHO steerage doc features a assertion to “contemplate referral sufferers with refractory hypoxemia regardless of lung-protective air flow in settings with entry to experience in ECLS.” Equally, america Middle for Illness Management offers interim steerage (https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html) for medical administration of COVID-19 sufferers with and with out acute respiratory misery syndrome (ARDS). The place ECLS experience is on the market, ECLS ought to be thought-about in accordance with the usual administration algorithm for ARDS in supporting sufferers with viral decrease respiratory tract an infection. Nevertheless, clearly, presently, there may be little worldwide expertise with utilizing ECLS to assist COVID-19 sufferers. ELSO leaders have mentioned the potential position of ECMO for COVID-19 sufferers in a latest Journal of the American Medical Affiliation Viewpoint (https://jamanetwork.com/journals/jama/articlepdf/2761778/jama_maclaren_2020_vp_200024.pdf). ELSO will proceed to gather knowledge by our member facilities by the ELSO Registry and supply suggestions as extra data turns into obtainable.

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