Impact of hemodialysis on circulating cystatin c ranges in sufferers with finish stage renal illness

Successful treatment of non-Hodgkin’s lymphoma with rituximab and dose-adjusted CHOP therapy in a patient with concomitant end-stage renal disease requiring haemodialysis
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Indian J Clin Biochem. 2010 Jan; 25(1): 43–46.

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Plasma cystatin C is an rising parameter to evaluate kidney perform. Its utility in assessing the adequacy of hemodialysis in sufferers with end-stage-renal illness has nonetheless not been established with certainty. This examine was due to this fact carried out to evaluate the usefulness of serum cystatin C estimation in sufferers present process low flux membrane hemodialysis. Serum creatinine and cystatin C had been estimated in 20 sufferers earlier than and after present process hemodialysis. The imply serum creatinine decreased from a pre-dialysis worth of seven.72 mg/dL to a post-dialysis worth of two.90 mg/dL. Quite the opposite, the imply serum cystatin C ranges had been discovered to extend from a pre-dialysis worth of 5.97 mg/L to a post-dialysis worth of 8.25 mg/L. Due to this fact, serum cystatin C can’t be used to observe dialysis adequacy. It nonetheless, serves as a surrogate marker of the inadequacy of low flux membrane bicarbonate hemodialysis in clearing low molecular weight proteins from the circulation.

Key Phrases: Hemodialysis, Pre-dialysis, Submit-dialysis, Cystatin C, Creatinine

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