Impact of hemodialysis on circulating cystatin c ranges in sufferers with finish stage renal illness

Successful treatment of non-Hodgkin’s lymphoma with rituximab and dose-adjusted CHOP therapy in a patient with concomitant end-stage renal disease requiring haemodialysis
May 29, 2021 0 Comments

Indian J Clin Biochem. 2010 Jan; 25(1): 43–46.

,4 ,4 ,1 ,corresponding author1,5 ,4 ,2 and 3

Summary

Plasma cystatin C is an rising parameter to evaluate kidney perform. Its utility in assessing the adequacy of hemodialysis in sufferers with end-stage-renal illness has nonetheless not been established with certainty. This examine was due to this fact carried out to evaluate the usefulness of serum cystatin C estimation in sufferers present process low flux membrane hemodialysis. Serum creatinine and cystatin C had been estimated in 20 sufferers earlier than and after present process hemodialysis. The imply serum creatinine decreased from a pre-dialysis worth of seven.72 mg/dL to a post-dialysis worth of two.90 mg/dL. Quite the opposite, the imply serum cystatin C ranges had been discovered to extend from a pre-dialysis worth of 5.97 mg/L to a post-dialysis worth of 8.25 mg/L. Due to this fact, serum cystatin C can’t be used to observe dialysis adequacy. It nonetheless, serves as a surrogate marker of the inadequacy of low flux membrane bicarbonate hemodialysis in clearing low molecular weight proteins from the circulation.

Key Phrases: Hemodialysis, Pre-dialysis, Submit-dialysis, Cystatin C, Creatinine

Full Textual content

The Full Textual content of this text is accessible as a PDF (112K).

Chosen References

These references are in PubMed. This will not be the entire listing of references from this text.

1. James G.D., Sealey J.E., Alderman M., Ljungman S., Mueller F.B., Pecker M.S., Laragh J.H. A longitudinal examine of urinary creatinine and creatinine clearance in regular topics. Race, intercourse, and age variations. Am J Hypertens. 1988;1:124–131. [PubMed] [Google Scholar]
2. Levey A.S. Controlling the epidemic of heart problems in power renal illness: the place can we begin? Am J Kidney Dis. 1998;32:S5–13. doi: 10.1053/ajkd.1998.v32.pm9820463. [PubMed] [CrossRef] [Google Scholar]
3. Berglund F., Killander J., Pompeius R. Impact of trimethoprimsulfamethoxazole on the renal excretion of creatinine in man. J Urol. 1975;114:802–803. [PubMed] [Google Scholar]
4. Gerard S.Ok., Khayan-Bashi H. Characterization of creatinine error in ketotic sufferers. The potential comparability of alkaline picrate strategies with an enzymatic technique. Am J Clin Pathol. 1985;84:659–664. [PubMed] [Google Scholar]
5. Levey A.S., Berg R.L., Gassman J.J., Corridor P.M., Walker W.G. Creatinine filtration, secretion and excretion throughout progressive renal illnesses. Modification of Food plan in Renal Ailments (MDRD) Research Group. Kidney Int. 1989;27:S73–S80. [PubMed] [Google Scholar]
6. Perrone R.D., Madias N.E., Levey A.S. Serum creatinine as an index of renal perform: new insights into previous ideas. Clin Chem. 1992;38:1933–1953. [PubMed] [Google Scholar]
7. Dharnidharka V.R., Kwon C.H., Stevens G. Serum cystatin C is superior to serum creatinine as a marker of kidney perform: a meta evaluation. Am J Kidney Dis. 2002;40:221–226. doi: 10.1053/ajkd.2002.34487. [PubMed] [CrossRef] [Google Scholar]
8. Newman D.J., Thakkar H., Edwards R.G., Wilkie M., White T., Grubb A.O., et al. Serum cystatin C measured by automated immunoassay: A extra delicate marker of adjustments in GFR than serum creatinine. Kidney Int. 1995;47:312–318. doi: 10.1038/ki.1995.40. [PubMed] [CrossRef] [Google Scholar]
9. Clarck W.R., Gao D. Low molecular weight proteins in finish stage renal illnesses: Potential toxicity and dialytic elimination mechanisms. J Am Soc Nephrol. 2002;13:S41–S47. [PubMed] [Google Scholar]
10. Randers E., Erlandsen E.J. Serum cystatin C as an endogenous marker of the renal perform — a overview. Clin Chem Lab Med. 1999;37:389–395. doi: 10.1515/CCLM.1999.064. [PubMed] [CrossRef] [Google Scholar]
11. Roos J.F., Doust J., Tett S.E., Kilpatrick C.M. Diagnostic accuracy of cystatin C is superior to creatinine for the estimation of renal dysfunction in adults and youngsters – a meta evaluation. Clin Biochem. 2007;40:383–391. doi: 10.1016/j.clinbiochem.2006.10.026. [PubMed] [CrossRef] [Google Scholar]
12. Campo A., Lanfranco G., Gramaglia L., Goia F., Cottino R., Giusto V., et al. May plasma cystatin C be helpful as a marker of hemodialysis low molecular weight proteins elimination? Nephron Clin Pract. 2004;98:c79–c82. doi: 10.1159/000080677. [PubMed] [CrossRef] [Google Scholar]
13. Monitini G., Amici G., Milan S., Mussap M., Naturale M., et al. Center molecule and small protein elimination in youngsters on peritoneal dialysis. Kidney Int. 2002;61:1153–1159. doi: 10.1046/j.1523-1755.2002.00216.x. [PubMed] [CrossRef] [Google Scholar]
14. Kabanda A., Jadoul M., Pochet J.M., Lauwerys R., Strihou C.A.Y., Bernard A., et al. Determinations of the serum concentrations of low molecular weight proteins in sufferers on upkeep hemodialysis. Kidney Int. 1994;45:1689–1696. doi: 10.1038/ki.1994.221. [PubMed] [CrossRef] [Google Scholar]
15. Shilpak M.G., Katz R., Sarnak M.J., Fried L.F., Newman A.B., Breen C.S., et al. Cystatin C and prognosis for cardiovascular and kidney outcomes in aged individuals with out power kidney illness. Ann Intern Med. 2006;145:237–245. [PubMed] [Google Scholar]


Articles from Indian Journal of Scientific Biochemistry are offered right here courtesy of Springer


Leave a Reply

Your email address will not be published. Required fields are marked *