NKF KDOQI Pointers

NKF KDOQI Guidelines
May 1, 2021 0 Comments

NKF KDOQI Pointers

Scientific Observe Pointers and Scientific Observe Suggestions
2006 Updates
Hemodialysis Adequacy
Peritoneal Dialysis Adequacy
Vascular Entry



The usage of aseptic method and acceptable cannulation strategies, the timing of fistula and graft cannulation, and early analysis of immature fistulae are all components that will forestall morbidity and will delay the survival of everlasting dialysis accesses.

3.1 Aseptic strategies:

  • 3.1.1 For all vascular accesses, aseptic method ought to be used for all cannulation and catheter accession procedures. (See Desk 2.) (A)

3.2 Maturation and cannulation of fistulae:

  • 3.2.1 A major fistula ought to be mature, prepared for cannulation with minimal threat for infiltration, and capable of ship the prescribed blood circulate all through the dialysis process. (See Desk 3.) (B)
  • 3.2.2 Fistulae usually tend to be useable once they meet the Rule of 6s traits: circulate larger than 600 mL/min, diameter at the very least 0.6 cm, not more than 0.6 cm deep, and discernible margins. (B)
  • 3.2.3 Fistula hand-arm train ought to be carried out. (B)
  • 3.2.4 If a fistula fails to mature by 6 weeks, a fistulogram or different imaging research ought to be obtained to find out the reason for the issue. (B)

3.3 Cannulation of AVGs:
Grafts usually shouldn’t be cannulated for at the very least 2 weeks after placement and never till swelling has subsided in order that palpation of the course of the graft might be carried out. The composite PU graft shouldn’t be cannulated for at the very least 24 hours after placement and never till swelling has subsided in order that palpation of the course of the graft might be carried out. Rotation of cannulation websites is required to keep away from pseudoaneurysm formation. (See Desk 4.) (B)

3.4 Dialysis catheters and port catheter methods:
An infection-control measures that ought to be used for all HD catheters and port catheter methods embrace the next:

  • 3.4.1 The catheter exit website or port cannulation website ought to be examined for correct place of the catheter/port catheter system and absence of an infection by skilled personnel at every HD session earlier than opening and accessing the catheter/port catheter system. (B)
  • 3.4.2 Altering the catheter exit-site dressing at every HD therapy, utilizing both a clear dressing or gauze and tape. (A)
  • 3.4.3 Utilizing aseptic method to stop contamination of the catheter or port catheter system, together with the usage of a surgical masks for workers and affected person and clear gloves for all catheter or port catheter system join, disconnect, and dressing procedures. (A)


There may be appreciable proof that the usage of maximal sterile precautions, versus clear aseptic method, for cannulation of AV accesses and catheter accession is each impractical and pointless.222-225 Nevertheless, the significance of strict dialysis precautions226 and aseptic method222 can’t be overemphasized within the prevention and minimization of all entry an infection.227 Regardless of the overall acceptance of the significance of normal precautions for hand washing and glove modifications, these easy acts to reduce transmission of illness often are skipped. An audit in a choice of Spanish HD items examined alternatives to put on gloves and wash arms per the usual preventive tips (high-risk actions of connection, disconnection, and make contact with between sufferers throughout dialysis). Gloves have been worn by solely 19% and arms have been washed after affected person contact on solely 32% of all events.228 Obligatory hand washing earlier than affected person contact occurred solely 3% of the time. A decade later, sporting of gloves improved to 92%, however the follow of hand washing earlier than or after these patient-oriented procedures remained low at 36% after and 14% earlier than such actions.229 Higher adherence was present in acute than in long-term HD items. A larger patient-nurse ratio independently influenced hand-washing charges. With the rising microbial resistance to mainstream antibiotics,230 an infection prevention should be thought of the primary rule of vascular entry upkeep.231 Information from potential research in each Canada and the US clearly present that nice variability exists between facilities in an infection charges, indicating the necessity to haven’t solely a nationwide registry, but additionally a neighborhood (ie, in-center) an infection surveillance program.232-234 Elevated consciousness on the particular person middle stage is vital to stemming entry an infection and its excessive penalties, equivalent to endocarditis and metastatic infections (eg, spinal abscesses), situations which can be disabling at greatest, typically deadly, and prohibitively pricey to deal with.235,236

Within the effort to stop an infection, it’s not solely workers that should be vigilant to potential breaks in method and the necessity for the suitable use of masks. Sufferers additionally should be taught that lapses of their use of masks and poor private hygiene are recognized to extend their threat for an infection. Sufferers with kind 2 diabetes are at elevated threat for nasal staphylococcal carriage and catheter-related bacteremia (CRB) in consequence.237,238

Maturation and Cannulation of Fistulae (CPG 3.2)
If the fistula is created with each sufficient influx artery and outflow vein, the elevated circulate within the vein ought to be instantly obvious postoperatively, evidenced by bigger look and the presence of a steady audible and palpable thrill alongside the vein, in addition to precise circulate measurements.126 Skilled workers ought to look at the fistula and the outflow vein every time the affected person involves dialysis to watch the maturation progress. Points of the bodily examination are summarized in Desk 5. The flexibility of “skilled, skilled dialysis nurses” to precisely predict eventual fistula maturity is superb.72 That is much more purpose to have a protocol for normal medical examination in place in dialysis facilities to show the abilities of bodily examination (see CPG 4 and CPG 5) to all workers members and assess the growing fistula and never deal with the entry in present use solely. The optimum time to do that examination is earlier than fluid removing as a result of hypotension can confound the findings. Sufferers who should not but on dialysis remedy ought to be taught learn how to carry out self-examination and be given acceptable contact info for questions and considerations. Poor prognostic indicators, equivalent to vital lower within the thrill, ought to be referred instantly again to the surgeon or the interventionalist for immediate analysis and intervention. At a minimal, all newly created fistulae should be bodily examined by utilizing an intensive systematic method by a educated skilled 4 to six weeks postoperatively to make sure acceptable maturation for cannulation.239 The steps for cannulation are summarized in Desk 3.

Protocol for Preliminary Cannulation of AVFs
If the bodily evaluation has proven that the fistula is satisfactorily matured, ideally, the subsequent step is to carry out a trial cannulation. Typically, the earliest that this case happens is when the vein diameter is larger than 0.4 cm, has a circulate larger than 500 mL/min,59 and at the very least 1 month has elapsed since fistula creation60 (Desk 3). If doable, the trial cannulation of the fistula ought to be executed on a nondialysis day. This serves to get rid of any potential problems related to the administration of heparin.

If a trial cannulation is just not doable, it’s best to carry out the preliminary cannulation of the brand new entry on the affected person’s midweek HD therapy. Performing the preliminary cannulation midweek helps keep away from such problems as fluid overload and elevated chemistry take a look at outcomes related to the weekends.

To make sure that the needle is positioned correctly, needle placement ought to be confirmed with a traditional saline flush earlier than connecting the needles to the blood pump and beginning the pump. Blood return alone is just not sufficient to indicate good needle placement. One possibility to simply test for correct needle placement is the usage of “moist” needles. The needle is purged of air and the saline within the hooked up syringe is used to flush the needle. If an infiltration has occurred, the traditional saline is much less dangerous to the encompassing AVF tissue. The moist needle additionally prevents the danger for a blood spray or spill if dry needles are used for cannulation and the caps are opened to “bleed out” the needle from the air. The opening of the needle is a threat for blood publicity to the dialysis workforce member, affected person, and close by sufferers. For these causes, use of a moist needle is a safer method for the AVF, affected person, and dialysis workforce members, particularly for the preliminary AVF cannulation. This feature ought to be thought of as a part of the dialysis unit’s cannulation coverage and procedures. The really helpful process is described subsequent.

  1. Connect a 10-mL syringe full of 8 mL of regular saline resolution to the AVF needle, however don’t prime the needle till instantly earlier than the cannulation.
  2. Grasp the fistula needle by the butterfly wings and prime the needle with regular saline till all of the air is purged. Clamp the needle closed. Take away the protecting cap and instantly proceed with the cannulation method.
  3. When the needle has superior into the vessel, blood flashback will probably be seen (the needle might must be unclamped to see the blood flashback) and, if seen, aspirate again 1 to five mL with the 10-mL syringe. Flush the needle with the traditional saline resolution and clamp. The syringe should aspirate and flush with ease. Monitor for indicators or signs of infiltration. Sufferers often expertise speedy sharp ache upon infiltration of saline or blood into the tissues.

Needle choice for the preliminary cannulation is crucial. One technique used to pick the suitable needle dimension is a visible and tactile examination. This examination permits the cannulator to find out which needle gauge could be most acceptable, based mostly on the dimensions of the vessels within the fistula. Alternately, place 17 G and 16 G needles with the protecting cap in place (prevents a needle stick) over the cannulation website. Evaluate the vein dimension with the needle dimension with and with out the tourniquet utilized. If the needle is bigger than the vein with the tourniquet, it’s too giant and will infiltrate with cannulation. Use the needle dimension that is the same as or smaller than the vein (with out the tourniquet) for the cannulation.

The smallest needle out there, often a 17 G, usually is used for preliminary cannulation makes an attempt. It is very important take into account that blood circulate delivered by a 17 G needle is proscribed. Prepump arterial monitoring is really helpful to make sure that blood pump pace doesn’t exceed that which the needle can present. Prepump arterial stress mustn’t exceed −250 mm Hg. Primarily based on efficiency of the fistula utilizing a 17 G needle, the choice to extend the needle dimension for subsequent cannulation might be made.

A needle with a again eye ought to at all times be used for the arterial needle to maximise the circulate from the entry and scale back the necessity for flipping the needle.

  1. Apply a tourniquet to the entry arm.
  2. After disinfecting the entry website per unit protocol, rigorously cannulate the fistula, utilizing a 25° insertion angle.
  3. When blood flash is noticed, flatten the angle of the needle, parallel to the pores and skin, and advance slowly. When the needle is within the vessel, take away the tourniquet and tape the needle securely per unit protocol.
  4. Assess for sufficient blood circulate by alternately aspirating and flushing the needle with a syringe.
  5. Assess rigorously for indicators of infiltration, ie, ache, swelling, or discoloration.
  6. Repeat steps 1 to five for the second needle.

Cannulation Ideas

  1. A fistula that solely works with a tourniquet in place remains to be underdeveloped, often due to influx stenosis, and wishes extra time or reevaluation by the VAT earlier than use.
  2. The mixed use of the brand new fistula and bridge vascular entry (ie, TCC as a return for blood) could also be obligatory till the fistula is properly developed.
  3. Cannulation carried out at a nonturnover time might present extra time for the cannulation process.

Infiltrations, Issues, and Ideas

  1. Infiltrations with the cannulation can happen earlier than dialysis, throughout dialysis with the blood pump working, or after dialysis with the needle removing.
  2. Monitor carefully for indicators and signs of infiltration. A fast response to a needle infiltration will help reduce injury to the entry.
  3. If the infiltration happens after the administration of heparin, care should be taken to correctly clot the needle tract and never the fistula. In some circumstances, the choice to depart the needle in place and cannulate one other website could also be acceptable. The speedy utility of ice will help lower the ache and dimension of the infiltration and will lower bleeding time.
  4. Use warning when taping needles. Keep away from lifting up on the needle after it’s within the vein. An improper needle flip or taping process could cause an infiltration.
  5. If the fistula is infiltrated, it’s best to relaxation the fistula for at the very least 1 therapy. If this isn’t doable, the subsequent cannulation ought to be above the positioning of the infiltration. If the affected person nonetheless has a catheter in place, restart use of the fistula with 1 needle and advance to 2 needles, bigger needle dimension, and larger BFRs because the entry permits.
  6. Correct needle removing prevents postdialysis infiltrations. Apply the gauze dressing over the needle website, however don’t apply stress. Rigorously take away the needle at roughly the identical angle because it was inserted. This prevents dragging the needle throughout the affected person’s pores and skin. Utilizing too steep of an angle throughout needle removing might trigger the needle’s leading edge to puncture the vein wall.
  7. Don’t apply stress to the puncture website till the needle has been fully eliminated.

Fistula Hand-Arm Train (CPG 3.2.3)
Strengthening the forearm by utilizing isometric workouts to extend handgrip energy (eg, squeezing a rubber ball with or with no frivolously utilized tourniquet) might improve blood circulate, thereby enhancing vein maturation,240 and has been proven to considerably improve forearm vessel dimension,127,241 thereby doubtlessly rising circulate via a fistula created utilizing these vessels. The ensuing muscle mass improve additionally might improve vein prominence. Train additionally might lower superficial fats. Correction of anemia additionally may improve cardiac output and reduce peripheral resistance, doubtlessly leading to elevated circulate via the fistula.

Entry Move for Dialysis in Fistulae (CPG 3.3)
After acceptable bodily examination, a fistulogram is the gold normal for evaluating poor maturation of the fistula if the affected person is already on dialysis remedy. Use of a non-nephrotoxic distinction materials, carbon dioxide, or ultrasound ought to be used for sufferers not but on dialysis remedy. Though a fistula can preserve patency at decrease blood flows than grafts, thrombosis nonetheless happens and, if not handled promptly, can result in everlasting lack of the entry. Thrombosis charges might be diminished by potential correction of issues.242 Supply of dialysis is circulate dependent: entry circulate lower than 350 mL/min is prone to produce recirculation and insufficient supply of dialysis. (See the HD Adequacy Pointers.) Some facilities have used diluted distinction (25%), and there are actually printed information that counsel this diluted distinction doesn’t adversely influence residual kidney operate.639 The pictures are of acceptable high quality. The suitable intervention for poor maturation is predicated on the reason for the dysfunction and will contain PTA of stenotic lesions, ligation or occlusion of vein branches (if the issue is just > 1 main outflow vein),122,243 and/or surgical intervention, together with revision of the anastomosis.75,125,126

Cannulation of AVGs (CPG 3.4)
Producers’ tips are based mostly on the time wanted for tissue-to-graft incorporation, thereby stopping the opportunity of a hematoma dissecting alongside the perigraft area. Nevertheless, most sufferers expertise vital tissue swelling on account of the tunneling, and palpation of the graft is troublesome for the cannulator and painful for the affected person.

Placement of a graft that enables for early cannulation could also be advantageous within the affected person who wants to start dialysis remedy, has no different entry, and doesn’t have veins appropriate for a fistula. Such an entry would preclude the need to position a catheter whereas a traditional graft matures. This kind of graft confers no further profit past early cannulation.114,119,128

Biografts usually tend to change into aneurysmal than PTFE grafts,116 and cannulation strategies ought to be a hybrid of the strategies for a graft relating to depth of the entry and the feel of an autogenous vein. Rotation of cannulation websites ought to be noticed in these grafts; nevertheless, fixed cannulation (buttonhole) has not been studied.244

Dialysis Catheters and Port Catheter Programs (CPG 3.5)
A dislodged (cuff uncovered) or doubtlessly contaminated catheter or exit website requires additional evaluation and probably an intervention earlier than being deemed secure to entry for dialysis.

The Facilities for Illness Management and Prevention (CDC) has no desire between clear dressing and gauze, besides within the case by which the exit website is oozing, which requires gauze.222 Customary follow is to scrub the exit website and redress at every dialysis therapy (see Desk 6).

Airborne contaminants from each sufferers and workers are prevented greatest by way of surgical masks when the catheter lumens or exit website are uncovered. Carrying clear gloves and avoiding touching uncovered surfaces additional decreases the danger for an infection. Aseptic method consists of minimizing the time that the catheter lumens or exit website are uncovered.222,226 Producers’ instructions ought to be adhered to for the sorts of disinfectants really helpful for secure cleansing of the pores and skin and system. If not contraindicated, the CDC recommends use of two% chlorhexidine,222 proven to be superior to povidone-iodine.245,246 Cautious consideration to hub care can lower the CRB fee nearly 4-fold to a fee approaching 1 episode/1,000 days.247


Lots of the tips are based mostly on good requirements of medical follow. These referring to the usage of “aseptic” method observe the suggestions of the CDC. It’s unlikely that randomized trials will ever be executed on this space.


Establishing Fixed-sites in Native Fistulae by Utilizing Customary Sharp Fistula Needles

  1. Carry out a whole bodily evaluation of the fistula and doc the findings.
  2. Choose the cannulation websites rigorously. Think about straight areas, needle orientation, and talent of the affected person to self-cannulate. Websites ought to be chosen in an space with out aneurysms and with a minimal of two inches between the information of the needles.
  3. Take away any scabs over the cannulation websites.
  4. Disinfect the cannulation websites per facility protocol.
  5. Utilizing a pointy fistula needle, grasp the needle wings and take away the tip protector. Align the needle cannula, with the bevel going through up, over the cannulation website and pull the pores and skin taut (Fig 1A).
  • Cannulate the positioning at a 25° angle; self-cannulators might require a steeper angle (Fig 1B). It is very important cannulate the growing constant-site entry in precisely the identical place, utilizing the identical insertion angle and depth of penetration every time.* This requires {that a} single cannulator carry out all cannulations till the websites are properly established.
  • A flashback of blood signifies the needle is within the entry. Decrease the angle of insertion. Proceed to advance the needle into the fistula till it’s appropriately positioned throughout the vessel (Fig 1C).
  • Securely tape the fistula needle (Fig 1D) and proceed with dialysis therapy per facility protocol.

Fig 1. Beginning a buttonhole. Reproduced with permission from Medisystems Inc.

*Be aware: It takes roughly 6-10 cannulations utilizing a pointy needle to create a scar tissue tunnel monitor. Arterial and venous websites might not develop on the similar fee. As soon as a scar tissue tunnel monitor is properly shaped, the antistick uninteresting bevel needles ought to be used. If normal sharp needles are used past the creation of the buttonhole websites, the scar tissue tunnel might be minimize. Extra stress and extra needle manipulation will probably be required to advance the antistick needle down the tunnel monitor. This could result in bleeding or oozing from the needle website throughout use on HD. The sharp needle may also puncture the vessel at a brand new website or trigger an infiltration. The short transition to the antistick needle will protect the integrity of the buttonhole website and forestall problems.

Cannulating Mature Fixed Websites in Native Fistulae Utilizing an Antistick Uninteresting Bevel

  1. Carry out a whole bodily evaluation of the fistula and doc the findings.
  2. Take away any scabs over the cannulation websites.
  3. Disinfect the cannulation websites per facility protocol.
  4. Utilizing an antistick uninteresting bevel, grasp the needle wings and take away the tip protector. Align the needle cannula, with the bevel going through up, over the cannulation website and pull the pores and skin taut (Fig 2A).*
  • Rigorously insert the needle into the established cannulation website (Fig 2B). Advance the needle alongside the scar tissue tunnel monitor. If gentle to reasonable resistance is met whereas making an attempt to insert the needle, rotate the needle as you advance it, utilizing light stress (Fig 2C).
  • A flashback of blood signifies when the needle is within the entry. Decrease the angle of insertion. Proceed to advance the needle into the fistula till it’s appropriately positioned throughout the vessel.
  • Securely tape the needle set (Fig 2D) and proceed with the dialysis therapy per facility protocol.

Fig 2. Cannulating a buttonhole. Reproduced with permission from Medisystems Inc.

*Be aware: Be sure that the identical needle insertion angle and depth of penetration are used constantly for every cannulation of a relentless website.

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