Penicillin G Benzathine Dosage Information with Precautions

What You Need to Know
December 13, 2020 0 Comments

Medically reviewed by Medication.com. Final up to date on Sep 12, 2019.

Applies to the next strengths: 1,200,000 models/2 mL; 600,000 models/mL; 2,400,000 models/4 mL

Typical Grownup Dose for:

Typical Pediatric Dose for:

Further dosage data:

Typical Grownup Dose for Pharyngitis

1.2 million models IM as a single dose

Makes use of: For the remedy of gentle to reasonable higher respiratory tract infections (URTIs) on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

Infectious Ailments Society of America (IDSA) and American Coronary heart Affiliation (AHA) Suggestions: 1.2 million models IM as a single dose

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Grownup Dose for Higher Respiratory Tract An infection

1.2 million models IM as a single dose

Makes use of: For the remedy of gentle to reasonable higher respiratory tract infections (URTIs) on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

Infectious Ailments Society of America (IDSA) and American Coronary heart Affiliation (AHA) Suggestions: 1.2 million models IM as a single dose

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Grownup Dose for Tonsillitis/Pharyngitis

1.2 million models IM as a single dose

Makes use of: For the remedy of gentle to reasonable higher respiratory tract infections (URTIs) on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

Infectious Ailments Society of America (IDSA) and American Coronary heart Affiliation (AHA) Suggestions: 1.2 million models IM as a single dose

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Grownup Dose for Streptococcal An infection

1.2 million models IM as a single dose

Makes use of: For the remedy of gentle to reasonable higher respiratory tract infections (URTIs) on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

Infectious Ailments Society of America (IDSA) and American Coronary heart Affiliation (AHA) Suggestions: 1.2 million models IM as a single dose

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Grownup Dose for Rheumatic Fever Prophylaxis

1.2 million models IM as soon as a month or 600,000 models IM each 2 weeks

Feedback:
-Prophylaxis with this drug is efficient in stopping recurrence of rheumatic fever and/or chorea.
-This drug has been used as follow-up prophylactic remedy for rheumatic coronary heart illness.

Makes use of: Prophylaxis towards rheumatic fever and/or chorea recurrence; prophylaxis for rheumatic fever after an acute assault

AHA Suggestions: 1.2 million models IM each 3 to 4 weeks

Length of secondary prophylaxis (after final assault):
-Rheumatic fever with carditis and residual coronary heart illness (persistent valvular illness): 10 years or till 40 years of age (whichever is longer); generally lifelong prophylaxis
-Rheumatic fever with carditis and no residual coronary heart illness (no valvular illness): 10 years or till 21 years of age (whichever is longer)
-Rheumatic fever with out carditis: 5 years or till 21 years of age (whichever is longer)

Feedback:
-Beneficial for secondary prevention of rheumatic fever (prevention of recurrent assaults)
-Use each 4 weeks is suitable for many conditions; use each 3 weeks is justified and really helpful for high-risk conditions.
-Present tips must be consulted for extra data.

Typical Grownup Dose for Syphilis – Early

2.4 million models IM as a single dose

Makes use of: For the remedy of main, secondary, and latent syphilis

US CDC Suggestions:
-Major, secondary, and early latent syphilis: 2.4 million models IM as a single dose
-Retreatment of main or secondary syphilis (with out neurosyphilis): 2.4 million models IM as soon as per week for 3 weeks
-Late latent syphilis or latent of unknown length: 2.4 million models IM as soon as per week for 3 weeks (whole dose: 7.2 million models)

Feedback:
-A second dose (2.4 million models IM) could be administered 1 week after the preliminary dose to pregnant ladies with main, secondary, or early latent syphilis.
-The affected person’s sexual companion(s) must also be evaluated/handled.
-Present tips must be consulted for extra data.

Typical Grownup Dose for Syphilis – Latent

2.4 million models IM as a single dose

Makes use of: For the remedy of main, secondary, and latent syphilis

US CDC Suggestions:
-Major, secondary, and early latent syphilis: 2.4 million models IM as a single dose
-Retreatment of main or secondary syphilis (with out neurosyphilis): 2.4 million models IM as soon as per week for 3 weeks
-Late latent syphilis or latent of unknown length: 2.4 million models IM as soon as per week for 3 weeks (whole dose: 7.2 million models)

Feedback:
-A second dose (2.4 million models IM) could be administered 1 week after the preliminary dose to pregnant ladies with main, secondary, or early latent syphilis.
-The affected person’s sexual companion(s) must also be evaluated/handled.
-Present tips must be consulted for extra data.

Typical Grownup Dose for Neurosyphilis

Bicillin L-A: 2.4 million models IM as soon as per week for 3 doses
Permapen: 3 million models IM as soon as per week for two to three doses (whole dose: 6 to 9 million models)

Use: For the remedy of late syphilis (tertiary and neurosyphilis)

US CDC Suggestions:
-Tertiary syphilis with regular CSF examination: 2.4 million models IM as soon as per week for 3 weeks (whole dose: 7.2 million models)
-Neurosyphilis (after finishing really helpful or various routine):2.4 million models IM as soon as per week for as much as 3 weeks

Feedback:
-Use of this drug could be thought of after finishing the really helpful (aqueous penicillin G) or various (procaine penicillin plus probenecid) routine for neurosyphilis to supply comparable whole length of remedy.
-The affected person’s sexual companion(s) must also be evaluated/handled.
-Present tips must be consulted for extra data.

Typical Grownup Dose for Tertiary Syphilis

Bicillin L-A: 2.4 million models IM as soon as per week for 3 doses
Permapen: 3 million models IM as soon as per week for two to three doses (whole dose: 6 to 9 million models)

Use: For the remedy of late syphilis (tertiary and neurosyphilis)

US CDC Suggestions:
-Tertiary syphilis with regular CSF examination: 2.4 million models IM as soon as per week for 3 weeks (whole dose: 7.2 million models)
-Neurosyphilis (after finishing really helpful or various routine):2.4 million models IM as soon as per week for as much as 3 weeks

Feedback:
-Use of this drug could be thought of after finishing the really helpful (aqueous penicillin G) or various (procaine penicillin plus probenecid) routine for neurosyphilis to supply comparable whole length of remedy.
-The affected person’s sexual companion(s) must also be evaluated/handled.
-Present tips must be consulted for extra data.

Typical Grownup Dose for Bejel

1.2 million models IM as a single dose

Typical Grownup Dose for Yaws

1.2 million models IM as a single dose

Typical Grownup Dose for Pinta

1.2 million models IM as a single dose

Typical Grownup Dose for Glomerulonephritis

1.2 million models IM as soon as a month or 600,000 models IM each 2 weeks

Feedback:
-This drug has been used as follow-up prophylactic remedy for acute glomerulonephritis.

Use: Prophylaxis for glomerulonephritis after an acute assault

Typical Pediatric Dose for Pharyngitis

Infants and pediatric sufferers lower than 27.3 kg: 300,000 to 600,000 models IM as a single dose
Older pediatric sufferers: 900,000 models IM as a single dose

Makes use of: For the remedy of gentle to reasonable URTIs on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

IDSA Suggestions:
-Kids lower than 27 kg: 600,000 models IM as a single dose
-Sufferers no less than 27 kg: 1.2 million models IM as a single dose

AHA and American Academy of Pediatrics (AAP) Suggestions:
-Kids as much as 27 kg: 600,000 models IM as soon as
-Sufferers higher than 27 kg: 1.2 million models IM as soon as

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA, AAP: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Higher Respiratory Tract An infection

Infants and pediatric sufferers lower than 27.3 kg: 300,000 to 600,000 models IM as a single dose
Older pediatric sufferers: 900,000 models IM as a single dose

Makes use of: For the remedy of gentle to reasonable URTIs on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

IDSA Suggestions:
-Kids lower than 27 kg: 600,000 models IM as a single dose
-Sufferers no less than 27 kg: 1.2 million models IM as a single dose

AHA and American Academy of Pediatrics (AAP) Suggestions:
-Kids as much as 27 kg: 600,000 models IM as soon as
-Sufferers higher than 27 kg: 1.2 million models IM as soon as

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA, AAP: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Tonsillitis/Pharyngitis

Infants and pediatric sufferers lower than 27.3 kg: 300,000 to 600,000 models IM as a single dose
Older pediatric sufferers: 900,000 models IM as a single dose

Makes use of: For the remedy of gentle to reasonable URTIs on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

IDSA Suggestions:
-Kids lower than 27 kg: 600,000 models IM as a single dose
-Sufferers no less than 27 kg: 1.2 million models IM as a single dose

AHA and American Academy of Pediatrics (AAP) Suggestions:
-Kids as much as 27 kg: 600,000 models IM as soon as
-Sufferers higher than 27 kg: 1.2 million models IM as soon as

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA, AAP: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Streptococcal An infection

Infants and pediatric sufferers lower than 27.3 kg: 300,000 to 600,000 models IM as a single dose
Older pediatric sufferers: 900,000 models IM as a single dose

Makes use of: For the remedy of gentle to reasonable URTIs on account of inclined group A streptococci (e.g., pharyngitis); for the remedy of URTIs (pharyngitis) on account of group A streptococci (with out bacteremia)

IDSA Suggestions:
-Kids lower than 27 kg: 600,000 models IM as a single dose
-Sufferers no less than 27 kg: 1.2 million models IM as a single dose

AHA and American Academy of Pediatrics (AAP) Suggestions:
-Kids as much as 27 kg: 600,000 models IM as soon as
-Sufferers higher than 27 kg: 1.2 million models IM as soon as

Feedback:
-Most well-liked for sufferers with group A streptococcal pharyngitis who’re thought of unlikely to finish 10 days of oral remedy
-IDSA: This drug plus 4 days of oral rifampin are really helpful for persistent carriers of group A streptococci.
-AHA, AAP: Beneficial for the remedy of streptococcal tonsillopharyngitis (main prevention of rheumatic fever)
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Rheumatic Fever Prophylaxis

AHA Suggestions:
-Kids as much as 27 kg: 600,000 models IM each 3 to 4 weeks
-Sufferers higher than 27 kg: 1.2 million models IM each 3 to 4 weeks

Length of secondary prophylaxis (after final assault):
-Rheumatic fever with carditis and residual coronary heart illness (persistent valvular illness): 10 years or till 40 years of age (whichever is longer); generally lifelong prophylaxis
-Rheumatic fever with carditis and no residual coronary heart illness (no valvular illness): 10 years or till 21 years of age (whichever is longer)
-Rheumatic fever with out carditis: 5 years or till 21 years of age (whichever is longer)

Feedback:
-Beneficial for secondary prevention of rheumatic fever (prevention of recurrent assaults)
-Use each 4 weeks is suitable for many conditions; use each 3 weeks is justified and really helpful for high-risk conditions.
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Congenital Syphilis

Lower than 2 years: 50,000 models/kg IM as a single dose
2 to 12 years: Modify dose based mostly on grownup dose schedule

Use: For the remedy of congenital syphilis (asymptomatic with regular CSF)

US CDC Suggestions:
Neonates:
-If congenital syphilis attainable, much less possible, or unlikely: 50,000 models/kg IM as a single dose
-With none scientific proof of an infection (congenital syphilis attainable or much less possible): 50,000 models/kg IM as a single dose

Infants and youngsters:
-If no scientific signs and regular analysis: 50,000 models/kg IM as soon as per week for as much as 3 weeks
-If scientific proof of congenital syphilis (after finishing the really helpful 10-day routine): 50,000 models/kg IM as a single dose
-With none scientific proof of an infection (congenital syphilis attainable or much less possible): 50,000 models/kg IM as a single dose

Most dose: 2.4 million models/dose

Feedback:
-If attainable congenital syphilis, neonates must be handled with this drug or one other really helpful routine; earlier than utilizing this single-dose routine, the entire analysis (i.e., CSF evaluation, long-bone radiographs, CBC with platelets) have to be regular, and follow-up have to be assured; if any a part of the analysis is irregular/not carried out, if the CSF evaluation can’t be interpreted on account of contamination with blood, or if follow-up is unsure, 10 days of penicillin G is required. If the nontreponemal check is nonreactive and the mom’s danger of untreated syphilis is deemed low, might take into account the single-dose routine to deal with neonates for attainable incubating syphilis with out an analysis
-If congenital syphilis is much less possible, an alternative choice to remedy with this drug is shut serologic follow-up (each 2 to three months for six months) for a neonate whose mom’s nontreponemal titers declined no less than 4-fold after applicable remedy for early syphilis or remained secure for low-titer, latent syphilis.
-Remedy isn’t required if congenital syphilis is unlikely; use of this drug could also be thought of, particularly if follow-up unsure and neonate has reactive nontreponemal check.
-Infants and youngsters with no scientific signs of congenital syphilis and whose analysis (together with CSF evaluation) is regular: Use of this drug could be thought of; a single dose could be thought of after finishing the really helpful routine (IV aqueous penicillin G for 10 days) to supply extra comparable length of remedy.
-Infants and youngsters with scientific proof of congenital syphilis: A single dose could be thought of after finishing the really helpful routine (procaine penicillin G for 10 days).
-Infants and youngsters with none scientific proof of an infection: A single dose could be thought of.
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Syphilis – Early

US CDC Suggestions:
1 month or older:
-Major, secondary, and early latent syphilis: 50,000 models/kg IM as a single dose
Most dose: 2.4 million models/dose

-Late latent syphilis: 50,000 models/kg IM as soon as per week for 3 weeks (whole dose: 150,000 models/kg)
Most dose: 2.4 million models/dose (most whole dose: 7.2 million models)

Feedback:
-Present tips must be consulted for extra data.

Typical Pediatric Dose for Syphilis – Latent

US CDC Suggestions:
1 month or older:
-Major, secondary, and early latent syphilis: 50,000 models/kg IM as a single dose
Most dose: 2.4 million models/dose

-Late latent syphilis: 50,000 models/kg IM as soon as per week for 3 weeks (whole dose: 150,000 models/kg)
Most dose: 2.4 million models/dose (most whole dose: 7.2 million models)

Feedback:
-Present tips must be consulted for extra data.

Renal Dose Changes

Information not obtainable

Liver Dose Changes

Information not obtainable

Dose Changes

In kids youthful than 12 years, dose must be adjusted in accordance with age and weight of the kid and severity of the an infection.

Precautions

US BOXED WARNING:
-ADMINISTRATION: This drug isn’t for IV use; it should not be injected IV or admixed with different IV options. Inadvertent IV administration of this drug has been related to cardiorespiratory arrest and demise. The producer product data must be consulted earlier than administering this drug.

CONTRAINDICATIONS:
Earlier hypersensitivity response to any of the penicillins

Seek the advice of WARNINGS part for extra precautions.

Dialysis

Information not obtainable

Different Feedback

Administration recommendation:
-For IM injection solely; don’t inject into or close to an artery or nerve; don’t inject IV or admix with different IV options.
-Administer by deep IM injection within the higher, outer quadrant of the buttock (dorsogluteal) or the ventrogluteal website; might favor the midlateral facet of the thigh in neonates, infants, and babies; for sufferers youthful than 2 years, might divide the dose between the two buttocks if wanted
-The needle could also be blocked if the drug isn’t injected at a sluggish, regular charge (on account of excessive focus of suspended materials in product).
-Rotate the injection website when doses are repeated.

Storage necessities:
-Retailer in fridge between 2C to 8C (36F to 46F)
-Hold from freezing.

Basic:
-This drug is for the remedy of infections on account of penicillin-G-sensitive microorganisms inclined to low and really extended serum drug ranges.
-Bacteriological research (together with sensitivity testing) and scientific response ought to information remedy.
-In streptococcal infections, remedy must be enough to eradicate the organism, in any other case streptococcal illness sequelae might happen; cultures must be taken after completion of remedy to confirm streptococci have been eradicated.
-Tradition and susceptibility data must be thought of when deciding on/modifying antibacterial remedy or, if no information can be found, native epidemiology and susceptibility patterns could also be thought of when deciding on empiric remedy.

Monitoring:
-Hematologic: Hematopoietic programs (throughout extended remedy, particularly with high-dose regimens)
-Renal: Renal programs (throughout extended remedy, particularly with high-dose regimens); renal perform in aged sufferers

Affected person recommendation:
-Keep away from lacking doses and full the complete course of remedy.
-Seek the advice of doctor directly if watery and bloody stools (with or with out abdomen cramps and fever) develop.

Additional data

At all times seek the advice of your healthcare supplier to make sure the knowledge displayed on this web page applies to your private circumstances.

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