Tizanidine Dosage Information with Precautions
Medically reviewed by Medicine.com. Final up to date on March 8, 2021.
Applies to the next strengths: 4 mg; 2 mg; 6 mg
Traditional Grownup Dose for:
Extra dosage info:
Traditional Grownup Dose for Muscle Spasm
Preliminary dose: 2 mg orally each 6 to eight hours as wanted
-Peak results happen in roughly 1 to 2 hours and final for 3 to six hours; remedy will be repeated as wanted to a most of three doses in 24 hours; step by step improve dose by 2 to 4 mg at intervals of 1 to 4 days till passable discount of muscle tone is achieved.
Most single dose: 16 mg
Most day by day dose: 36 mg in 24 hours
-Clinically vital variations in absorption are anticipated between capsules and tablets when taken with or with out meals; these variations might end in modifications in efficacy and tolerability.
-As soon as a formulation is set on and a choice is made to take with or with out meals, this routine shouldn’t be altered.
Use: Administration of spasticity.
Renal Dose Changes
Extreme renal impairment (CrCl lower than 25 mL/min): Individualize remedy with decrease doses throughout dose titration; if larger doses are required, particular person doses must be elevated slightly rising the dosing frequency; intently monitor for toxicity
Liver Dose Changes
Not really helpful
Use with warning in aged sufferers, particularly these with renal impairment.
-Lower by 2 to 4 mg per day, particularly in sufferers who’ve been receiving doses of 20 to 36 mg per day for intervals of 9 weeks or extra.
Security and efficacy haven’t been established in sufferers youthful than 18 years.
Seek the advice of WARNINGS part for extra precautions.
Information not accessible
-Could take orally with or with out meals; nonetheless, as soon as a formulation is set on and a choice is made to take with or with out meals, this routine shouldn’t be altered.
-As a result of this drug has a comparatively quick period of impact, dosing ought to happen at instances when reduction of spasticity is most vital, similar to earlier than actions of day by day residing.
-Appreciable variation in response has been noticed and due to this fact cautious titration is critical with the intention to not exceed the dose producing the specified impact.
-Gradual dose discount is suggested on discontinuation in order to reduce danger of withdrawal and rebound hypertension, tachycardia, and hypertonia.
-Receive aminotransferase ranges at baseline, 1 month after most dose is achieved, and as clinically indicated (e.g. if hepatic damage is suspected).
-Take into account acquiring baseline renal perform in aged sufferers.
-Monitor for hypotension in at-risk sufferers and people receiving concomitant antihypertensive remedy.
-Monitor for sedation in sufferers receiving concomitant CNS depressant brokers.
Affected person recommendation:
-Sufferers could take this drug with or with out meals, however as soon as the choice is made to take with or with out meals it must be taken this fashion constantly.
-Sufferers ought to test with their healthcare supplier earlier than beginning or stopping any drugs as this drug is understood to work together with different drugs.
-Sufferers must be suggested to not abruptly cease taking this remedy with out first speaking with their healthcare supplier.
-Sufferers must be suggested that this drug could trigger hypotension and they need to watch out when altering positions kind mendacity to standing.
-Sufferers must be suggested this drug could trigger vital somnolence, particularly if taken with different CNS depressants or alcohol; they need to chorus from actions requiring psychological alertness till the consequences of the drug are recognized.
Extra about tizanidine
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Associated remedy guides
All the time seek the advice of your healthcare supplier to make sure the data displayed on this web page applies to your private circumstances.